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Field	Current Value	Updated change
Name	SMART
Full name	Sensor for MLKL Activation by RIPK3 based on FRET
Target	MLKL	2OG - 2-Oxoglutarate 3CLPro - 3prime IP - 3prime phosphoinositides 5-HT - 5-hydroxytryptamine (Serotonin) A1R - adenosine receptor A1 Abl - Abelson murine leukemia viral oncogene homolog 1 AC - Adenylyl Cyclase ACh - Acetylcholine ADP - Adenosine diphosphate Akt - Protein Kinase B alpha2A-AR - alpha2A-adrenergic receptor Ammonium - Ammonium AMPK - adenosine monophosphate-activated protein kinase (AMPK) Annexin 4 - Annexin 4 Arabinose - Arabinose Arg - Arginine As3+ - Arsenic ion aspartate - L-aspartate Atg4a - Autophagy Related 4A Cysteine Peptidase Atg4b - Autophagy Related 4B Cysteine Peptidase ATM kinase - ATM kinase ATP - Adenosine triphosphate ATP:ADP Ratio - Aurora B kinase - Aurora B kinase Aurora Kinase A - Aurora Kinase A B-Raf - B-Raf Bax - Bcl-2-associated X protein BCAA - Branched-chain amino acid Bcr-Abl - Oncogenic fusion of Bcr and Abl genes BDNF - Brain-derived neurotrophic factor beta Arrestin 2 - beta Arrestin 2 Beta1-AR - Beta 1 Adrenergic Receptor Beta2-AR - Beta 2 Adrenergic Receptor C-Raf - proto-oncogene serine/threonine-protein kinase Ca2+ - Calcium Ion CaM - Calmodulin 1 CaMKII - Calcium/calmodulin-dependent protein kinase II cAMP - cyclic adenosine monophosphate CaN - Calcineurin | Protein Phosphatase 3 Caspase1 - Caspase 1 Caspase3 - Caspase 3 Caspase8 - Caspase 8 Caspase9 - Caspase 9 Cd2+ - Cadmium Ion Cdc42 - Cell division control protein 42 homolog CDK1 - Cyclin-Dependent Kinase 1 CDK2 - Cyclin-dependent Kinase 2 Cell Cycle Phases - Progression through the cell cycle cGMP - Cyclic guanosine monophosphate Citrate - Citrate CO - Carbon Monoxide CRAC - Cytosolic Regulator of Adenylyl Cyclase CREB - cAMP-responsive element-binding protein Cu+ - Copper DAG - Diacylglycerol DAPK1 - Death associated protein kinase 1 Dictyostelium GPCR - Dictyostelium GPCR DNA methylation - DNA cytosine-C5 methylation Dopamine - Dopamine DRD2 - Dopamine Receptor D2 eCB - Endocannabinoid EGFR - Epidermal Growth Factor Receptor Enterokinase - ERK - Extracellular Signal-Regulated Kinase | Mitogen-activated protein kinase 1 F-1,6-BP - fructose‐1,6‐bisphosphate FAK - Focal Adhesion Kinase Fus3 - Fus3 Yeast MAPK FZD4 - Frizzled 4 FZD5 - Frizzled 5 FZD6 - Frizzled 6 FZD7 - Frizzled 7 G1 Phase - Cell Cycle G1 Phase GABA - gamma-Aminobutyric acid GCK - Glucokinase Gα - G protein α subunits Gαi - Gi alpha subunit Gαq - Gq α subunit Gαs - Gs alpha subunit Gln - Glutamine Glucose - Glucose Glutamate - Glutamate Glycine - GTP - Guanosine Triphosphate H2O2 - hydrogen peroxide H2S - hyrdogen sulfide H3-S10p - H3-S28p - Histone 3 phosphorylation at S28 H3K9me3 - Histone H3 Lysine 9 trimethylation H3R - Histamine H3 receptor Halide Ions - Halide Ions (Cl-, I-) Heme - Heme Heterotrimeric G Proteins - Hg(II) - Mercury His - Histidine Histone Acetylation - Histone Acetylation Ins(1,3,4,5)P4 - inositol-1,3,4,5-tetrakisphosphate INSR - Insulin Receptor Insulin - Insulin IP3 - inositol 1,4,5-trisphosphate α1-AR - α1 adrenergic receptor α2A-AR - α2A adrenergic receptor JNK - c-Jun N-terminal kinase K+ - Potassium K27H3 methyltransferase - K27H3 histone methyltransferase K9H3 methyltransferase - K9H3 methyltransferase kappa-opioid receptor - Kss1 - Kss1 Yeast MAPK Lactate - Lactate LATS - Large Tumor Suppressor Kinase 1 LCACoAs - long-chain fatty acyl-CoA esters Lck - Lck tyrosine kinase Ln3+ - lanthanides LTCC - L-Type Calcium Channel M1R - Muscarinic 1 Receptor M3R - M3 Muscarinic Receptor malonyl-CoA - maltose - maltose MAPK or MK2 - MAP kinase-activated protein kinase 2 MARK - Microtubule affinity regulating kinase Matriptase - Mechanical Strain - Mechanical Strain MEK - Mitogen-activated protein kinase kinase 1 Mg2+ - magnesium Mkk2 - Mkk2 Yeast MAPKK MLKL - Mixed Lineage Kinase Domain-Like Pseudokinase Mn2+ - Manganese ion Molecular crowding - Mpk1 - Mpk1 Yeast MAPK Mpro - MT1-MMP - Membrane Type 1 Metalloprotease MT2 - Melatonin Type-2 Receptor mTORC1 - mechanistic Target of Rapamycin Complex 1 mu-opioid receptor - N-WASP - neuronal Wiskott-Aldrich Syndrome protein NAD+ - NAD+/NADH Ratio - Nicotinamide adenine dinucleotide NADH - Nicotinamide adenine dinucleotide NADP+ - NADP+ NADP+:NADPH Ratio - NADP+:NADPH Ratio NADPH - NADPH NE - Norepinephrine Nicotine - Nicotine NO - Nitric Oxide O2 - Molecular oxygen ODR-10 - Odorant receptor OGT - O-GlcNAc Transferase OHP - Organic Hyrdroperoxides ONOO- - peroxynitrite opsin - opsin receptors Orexin Neuropeptide - Oxytocin - p38 - P38 mitogen-activated protein kinases PA - Phosphatidic acid PAK1 - P21-activated kinase 1 PDE - Phosphodiesterase PDGFR - Platelet-derived growth factor receptor PDK1 - phosphoinositide-dependent kinase 1 pH - pH Phosphate - PO4(-2) PI(3)P - phosphatidylinositol 3-phosphate PI(3,4)P2 - phosphatidylinositol 3,4-diphosphate PI(3,5)P2 - phosphatidylinositol 3,5-diphosphate PI(4)P - phosphatidylinositol4-phosphate PI(4,5)P2 - phosphatidylinositol 4,5-diphosphate PIP3 - phosphatidylinositol 3,4,5-triphosphate PIP5K - Phosphatidylinositol-4-phosphate 5- kinase PKA - Protein Kinase A PKC - Protein Kinase C PKD - Protein Kinase D PKM2 - Pyruvate Kinase M2 PLC - Phospholipase C PMCA - Plasma Membrane Ca2+ ATPase Pn - Phosphonate PS - phosphatidylserine PTEN - phosphatase and tensin homologue PTH1R - parathyroid hormone receptor 1 PTHR - Parathyroid Hormone Receptor Pyruvate - Pyruvate Rab13 - Rab5 - Ras-related protein Rab-5 Rac1 - Ras-related C3 botulinum toxin substrate 1 Rac2 - Ras-related C3 botulinum toxin substrate 2 Rac3 - Ras-related C3 botulinum toxin substrate 3 Raf1 - MAP3K Ral - Ras-related protein Rao Ran - RAs-related Nuclear protein Rap1 - Ras Proximate 1 Ras - Rat Sarcoma redox status - redox status RhoA - Ras homolog gene family, member A RhoB - Ras Homolog Family Member B RhoC - Rho C RhoQ - Ras Homolog Family Member Q ribose - ribose ROCK - Rho-associated protein kinase ROS - Reactive Oxygen Species ROS - RRas - Ras-related protein R-Ras RSK - ribosomal s6 kinase RTK - Receptor Tyrosine Kinases S Phase - Cell Cycle S Phase S6K - S6 kinase SAP3K - stress-activated protein kinases SnRK2.6/OST1 - Sucrose non-fermenting-1-related protein kinase 2.6/Open Stomata 1 SnRK2.6/OST1 - Sucrose non-fermenting-1-related protein kinase 2.6/Open Stomata 1 SOS - Son of sevenless homolog 1 Src - Proto-oncogene tyrosine-protein kinase Ste7 - Ste7 Yeast MAPKK sterol - sucrose - sucrose superoxide - super oxide Temperature - tempFix - tete tete - tete TEV - Tobacco Etch Virus Trehalose - trehalose TrkB - Tropomyosin receptor kinase B Trp - Tryptophan Ubiquitination - general ubiquitination V+ - Voltage VEGF - Vascular endothelial growth factor ZAP-70 - ZAP-70 Tyrosine kinase Zn2+ - Zinc Ion
Sensing Type	binding	Select Type ... phosphorylation binding other

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Affected biosensors

Name	Full name	Target	Pubmed ID
mSMART	murine Sensor for MLKL Activation by RIPK3 based on FRET	MLKL	30367066
hSMART	human Sensor for MLKL Activation by RIPK3 based on FRET	MLKL	30367066