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Field	Current Value	Updated change
Name	FIRE
Full name	fluorescent InsP3-responsive element
Target	IP3	2OG - 2-Oxoglutarate 3CLPro - 3prime IP - 3prime phosphoinositides 5-HT - 5-hydroxytryptamine (Serotonin) A1R - adenosine receptor A1 Abl - Abelson murine leukemia viral oncogene homolog 1 AC - Adenylyl Cyclase ACh - Acetylcholine ADP - Adenosine diphosphate Akt - Protein Kinase B alpha2A-AR - alpha2A-adrenergic receptor Ammonium - Ammonium AMPK - adenosine monophosphate-activated protein kinase (AMPK) Annexin 4 - Annexin 4 Arabinose - Arabinose Arg - Arginine As3+ - Arsenic ion aspartate - L-aspartate Atg4a - Autophagy Related 4A Cysteine Peptidase Atg4b - Autophagy Related 4B Cysteine Peptidase ATM kinase - ATM kinase ATP - Adenosine triphosphate ATP:ADP Ratio - Aurora B kinase - Aurora B kinase Aurora Kinase A - Aurora Kinase A B-Raf - B-Raf Bax - Bcl-2-associated X protein BCAA - Branched-chain amino acid Bcr-Abl - Oncogenic fusion of Bcr and Abl genes BDNF - Brain-derived neurotrophic factor beta Arrestin 2 - beta Arrestin 2 Beta1-AR - Beta 1 Adrenergic Receptor Beta2-AR - Beta 2 Adrenergic Receptor C-Raf - proto-oncogene serine/threonine-protein kinase Ca2+ - Calcium Ion CaM - Calmodulin 1 CaMKII - Calcium/calmodulin-dependent protein kinase II cAMP - cyclic adenosine monophosphate CaN - Calcineurin | Protein Phosphatase 3 Caspase1 - Caspase 1 Caspase3 - Caspase 3 Caspase8 - Caspase 8 Caspase9 - Caspase 9 Cd2+ - Cadmium Ion Cdc42 - Cell division control protein 42 homolog CDK1 - Cyclin-Dependent Kinase 1 CDK2 - Cyclin-dependent Kinase 2 Cell Cycle Phases - Progression through the cell cycle cGMP - Cyclic guanosine monophosphate Citrate - Citrate CO - Carbon Monoxide CRAC - Cytosolic Regulator of Adenylyl Cyclase CREB - cAMP-responsive element-binding protein Cu+ - Copper DAG - Diacylglycerol DAPK1 - Death associated protein kinase 1 Dictyostelium GPCR - Dictyostelium GPCR DNA methylation - DNA cytosine-C5 methylation Dopamine - Dopamine DRD2 - Dopamine Receptor D2 eCB - Endocannabinoid EGFR - Epidermal Growth Factor Receptor Enterokinase - ERK - Extracellular Signal-Regulated Kinase | Mitogen-activated protein kinase 1 F-1,6-BP - fructose‐1,6‐bisphosphate FAK - Focal Adhesion Kinase Fus3 - Fus3 Yeast MAPK Fyn - Proto-oncogene tyrosine-protein kinase Fyn FZD4 - Frizzled 4 FZD5 - Frizzled 5 FZD6 - Frizzled 6 FZD7 - Frizzled 7 G1 Phase - Cell Cycle G1 Phase GABA - gamma-Aminobutyric acid GCK - Glucokinase Gα - G protein α subunits Gαi - Gi alpha subunit Gαq - Gq α subunit Gαs - Gs alpha subunit Gln - Glutamine Glucose - Glucose Glutamate - Glutamate Glycine - GTP - Guanosine Triphosphate H2O2 - hydrogen peroxide H2S - hyrdogen sulfide H3-S10p - H3-S28p - Histone 3 phosphorylation at S28 H3K9me3 - Histone H3 Lysine 9 trimethylation H3R - Histamine H3 receptor Halide Ions - Halide Ions (Cl-, I-) Heme - Heme Heterotrimeric G Proteins - Hg(II) - Mercury His - Histidine Histone Acetylation - Histone Acetylation Ins(1,3,4,5)P4 - inositol-1,3,4,5-tetrakisphosphate INSR - Insulin Receptor Insulin - Insulin IP3 - inositol 1,4,5-trisphosphate α1-AR - α1 adrenergic receptor α2A-AR - α2A adrenergic receptor JNK - c-Jun N-terminal kinase K+ - Potassium K27H3 methyltransferase - K27H3 histone methyltransferase K9H3 methyltransferase - K9H3 methyltransferase kappa-opioid receptor - Kss1 - Kss1 Yeast MAPK Lactate - Lactate LATS - Large Tumor Suppressor Kinase 1 LCACoAs - long-chain fatty acyl-CoA esters Lck - Lck tyrosine kinase Ln3+ - lanthanides LTCC - L-Type Calcium Channel M1R - Muscarinic 1 Receptor M3R - M3 Muscarinic Receptor malonyl-CoA - maltose - maltose MAPK or MK2 - MAP kinase-activated protein kinase 2 MARK - Microtubule affinity regulating kinase Matriptase - Mechanical Strain - Mechanical Strain MEK - Mitogen-activated protein kinase kinase 1 Mg2+ - magnesium Mkk2 - Mkk2 Yeast MAPKK MLKL - Mixed Lineage Kinase Domain-Like Pseudokinase Mn2+ - Manganese ion Molecular crowding - Mpk1 - Mpk1 Yeast MAPK Mpro - MT1-MMP - Membrane Type 1 Metalloprotease MT2 - Melatonin Type-2 Receptor mTORC1 - mechanistic Target of Rapamycin Complex 1 mu-opioid receptor - N-WASP - neuronal Wiskott-Aldrich Syndrome protein NAD+ - NAD+/NADH Ratio - Nicotinamide adenine dinucleotide NADH - Nicotinamide adenine dinucleotide NADP+ - NADP+ NADP+:NADPH Ratio - NADP+:NADPH Ratio NADPH - NADPH NE - Norepinephrine Nicotine - Nicotine NO - Nitric Oxide O2 - Molecular oxygen ODR-10 - Odorant receptor OGT - O-GlcNAc Transferase OHP - Organic Hyrdroperoxides ONOO- - peroxynitrite opsin - opsin receptors Orexin Neuropeptide - Oxytocin - p38 - P38 mitogen-activated protein kinases PA - Phosphatidic acid PAK1 - P21-activated kinase 1 PDE - Phosphodiesterase PDGFR - Platelet-derived growth factor receptor PDK1 - phosphoinositide-dependent kinase 1 pH - pH Phosphate - PO4(-2) PI(3)P - phosphatidylinositol 3-phosphate PI(3,4)P2 - phosphatidylinositol 3,4-diphosphate PI(3,5)P2 - phosphatidylinositol 3,5-diphosphate PI(4)P - phosphatidylinositol4-phosphate PI(4,5)P2 - phosphatidylinositol 4,5-diphosphate PIP3 - phosphatidylinositol 3,4,5-triphosphate PIP5K - Phosphatidylinositol-4-phosphate 5- kinase PKA - Protein Kinase A PKC - Protein Kinase C PKD - Protein Kinase D PKM2 - Pyruvate Kinase M2 PLC - Phospholipase C PMCA - Plasma Membrane Ca2+ ATPase Pn - Phosphonate PS - phosphatidylserine PTEN - phosphatase and tensin homologue PTH1R - parathyroid hormone receptor 1 PTHR - Parathyroid Hormone Receptor Pyruvate - Pyruvate Rab13 - Rab5 - Ras-related protein Rab-5 Rac1 - Ras-related C3 botulinum toxin substrate 1 Rac2 - Ras-related C3 botulinum toxin substrate 2 Rac3 - Ras-related C3 botulinum toxin substrate 3 Raf1 - MAP3K Ral - Ras-related protein Rao Ran - RAs-related Nuclear protein Rap1 - Ras Proximate 1 Ras - Rat Sarcoma redox status - redox status Rho - Ras homology family RhoA - Ras homolog gene family, member A RhoB - Ras Homolog Family Member B RhoC - Rho C RhoQ - Ras Homolog Family Member Q ribose - ribose ROCK - Rho-associated protein kinase ROS - Reactive Oxygen Species ROS - RRas - Ras-related protein R-Ras RSK - ribosomal s6 kinase RTK - Receptor Tyrosine Kinases S Phase - Cell Cycle S Phase S6K - S6 kinase SAP3K - stress-activated protein kinases SnRK2.6/OST1 - Sucrose non-fermenting-1-related protein kinase 2.6/Open Stomata 1 SnRK2.6/OST1 - Sucrose non-fermenting-1-related protein kinase 2.6/Open Stomata 1 SOS - Son of sevenless homolog 1 Src - Proto-oncogene tyrosine-protein kinase Ste7 - Ste7 Yeast MAPKK sterol - sucrose - sucrose superoxide - super oxide Temperature - tempFix - tete tete - tete TEV - Tobacco Etch Virus Trehalose - trehalose TrkB - Tropomyosin receptor kinase B Trp - Tryptophan Ubiquitination - general ubiquitination V+ - Voltage VEGF - Vascular endothelial growth factor ZAP-70 - ZAP-70 Tyrosine kinase Zn2+ - Zinc Ion (Under review) alpha1-AR - α1-adrenergic receptor (Under review) Beta Arrestin - (Under review) Beta Arrestin 1 - Beta Arrestin 1 (Under review) Gα13 - (Under review) Gβγ - (Under review) GSH - Reduced glutathione (Under review) lactate/Pyruvate ratio - (Under review) PAR1 - Protease-activated receptor-1
Sensing Type	binding	Select Type ... phosphorylation binding other

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Affected biosensors

Name	Full name	Target	Pubmed ID
FIRE-1	fluorescent InsP3-responsive element	IP3	16249182
FIRE-2	fluorescent InsP3-responsive element	IP3	16249182
FIRE-3	fluorescent InsP3-responsive element	IP3	16249182