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List of Signaling Connections
Source
Target
Regulation
Type
Ref. PMID
Edit
1
Select source molecule ...
PKA
cAMP
PKC
DAG
Akt
PDE
AC
PIP3
PKD
Ca2+
PI(4,5)P2
ERK
MEK
Raf1
CaN
CaM
LTCC
EGFR
SOS
Src
Abl
mTORC1
Ras
Rac1
IP3
Rap1
RhoA
Gαi
Gαs
Gαq
Ste7
Fus3
Mkk2
Kss1
Mpk1
JNK
p38
Cdc42
N-WASP
RhoQ
Rab5
Ral
RRas
beta Arrestin 2
K9H3 methyltransferase
K27H3 methyltransferase
OGT
H3-S28p
V+
ROS
PLC
PI(3,4)P2
3prime IP
PS
PA
PI(3,5)P2
ATP
NAD+/NADH Ratio
CaMKII
H2O2
Caspase3
Halide Ions
Bcr-Abl
Histone Acetylation
G1 Phase
S Phase
cGMP
INSR
B-Raf
C-Raf
DAPK1
MAPK or MK2
PAK1
PDK1
AMPK
Aurora B kinase
Glutamate
PKM2
CDK1
ATM kinase
FAK
MARK
RSK
S6K
SAP3K
Beta2-AR
CREB
ROCK
Caspase8
CRAC
Phosphate
Zn2+
Lactate
Pyruvate
Cell Cycle Phases
RTK
pH
Cd2+
NO
OHP
redox status
superoxide
ONOO-
H2S
Caspase9
Aurora Kinase A
MT1-MMP
Glucose
2OG
O2
Ubiquitination
Caspase1
Annexin 4
RhoC
NADPH
Hg(II)
VEGF
PTEN
PI(4)P
PIP5K
Bax
Mechanical Strain
Lck
ZAP-70
Atg4a
Atg4b
CDK2
Insulin
PMCA
maltose
ribose
sucrose
His
Arabinose
Gln
Citrate
CO
Arg
Cu+
GCK
M1R
Trp
Ammonium
Heme
Pn
PTHR
α2A-AR
opsin
BDNF
α1-AR
A1R
Ran
Trehalose
ACh
Dopamine
NE
5-HT
ODR-10
PI(3)P
LATS
PDGFR
DRD2
Dictyostelium GPCR
Molecular crowding
Glycine
Rac2
RhoB
Rac3
GABA
Beta1-AR
kappa-opioid receptor
mu-opioid receptor
MT2
NAD+
ATP:ADP Ratio
NADP+
NADP+:NADPH Ratio
Mg2+
TrkB
Ins(1,3,4,5)P4
NADH
MLKL
H3-S10p
K+
Nicotine
BCAA
ADP
malonyl-CoA
sterol
SnRK2.6/OST1
SnRK2.6/OST1
DNA methylation
H3K9me3
F-1,6-BP
Rab13
FZD4
FZD5
FZD6
FZD7
alpha2A-AR
PTH1R
H3R
Ln3+
tete
tempFix
LCACoAs
GTP
As3+
Mn2+
Orexin Neuropeptide
eCB
Oxytocin
TEV
Mpro
3CLPro
Enterokinase
Matriptase
ROS
M3R
Heterotrimeric G Proteins
Gα
Temperature
aspartate
Select target molecule ...
PKA
cAMP
PKC
DAG
Akt
PDE
AC
PIP3
PKD
Ca2+
PI(4,5)P2
ERK
MEK
Raf1
CaN
CaM
LTCC
EGFR
SOS
Src
Abl
mTORC1
Ras
Rac1
IP3
Rap1
RhoA
Gαi
Gαs
Gαq
Ste7
Fus3
Mkk2
Kss1
Mpk1
JNK
p38
Cdc42
N-WASP
RhoQ
Rab5
Ral
RRas
beta Arrestin 2
K9H3 methyltransferase
K27H3 methyltransferase
OGT
H3-S28p
V+
ROS
PLC
PI(3,4)P2
3prime IP
PS
PA
PI(3,5)P2
ATP
NAD+/NADH Ratio
CaMKII
H2O2
Caspase3
Halide Ions
Bcr-Abl
Histone Acetylation
G1 Phase
S Phase
cGMP
INSR
B-Raf
C-Raf
DAPK1
MAPK or MK2
PAK1
PDK1
AMPK
Aurora B kinase
Glutamate
PKM2
CDK1
ATM kinase
FAK
MARK
RSK
S6K
SAP3K
Beta2-AR
CREB
ROCK
Caspase8
CRAC
Phosphate
Zn2+
Lactate
Pyruvate
Cell Cycle Phases
RTK
pH
Cd2+
NO
OHP
redox status
superoxide
ONOO-
H2S
Caspase9
Aurora Kinase A
MT1-MMP
Glucose
2OG
O2
Ubiquitination
Caspase1
Annexin 4
RhoC
NADPH
Hg(II)
VEGF
PTEN
PI(4)P
PIP5K
Bax
Mechanical Strain
Lck
ZAP-70
Atg4a
Atg4b
CDK2
Insulin
PMCA
maltose
ribose
sucrose
His
Arabinose
Gln
Citrate
CO
Arg
Cu+
GCK
M1R
Trp
Ammonium
Heme
Pn
PTHR
α2A-AR
opsin
BDNF
α1-AR
A1R
Ran
Trehalose
ACh
Dopamine
NE
5-HT
ODR-10
PI(3)P
LATS
PDGFR
DRD2
Dictyostelium GPCR
Molecular crowding
Glycine
Rac2
RhoB
Rac3
GABA
Beta1-AR
kappa-opioid receptor
mu-opioid receptor
MT2
NAD+
ATP:ADP Ratio
NADP+
NADP+:NADPH Ratio
Mg2+
TrkB
Ins(1,3,4,5)P4
NADH
MLKL
H3-S10p
K+
Nicotine
BCAA
ADP
malonyl-CoA
sterol
SnRK2.6/OST1
SnRK2.6/OST1
DNA methylation
H3K9me3
F-1,6-BP
Rab13
FZD4
FZD5
FZD6
FZD7
alpha2A-AR
PTH1R
H3R
Ln3+
tete
tempFix
LCACoAs
GTP
As3+
Mn2+
Orexin Neuropeptide
eCB
Oxytocin
TEV
Mpro
3CLPro
Enterokinase
Matriptase
ROS
M3R
Heterotrimeric G Proteins
Gα
Temperature
aspartate
Select regulation type ...
Positive/Activating
Negative/Inhibiting
Neutral
Select interaction type ...
phosphorylation
dephosphorylation
binding
degradation
creation
transport
ubiquitination
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2
Ca2+
Ca2+
Positive/Activating
transport
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